An investigation of the epigenetic and transcriptional.

Jabre, I. 2019. Understanding the epigenetics of alternative splicing in Arabidopsis thaliana. PhD Thesis Canterbury Christ Church University Faculty of Social and Applied Sciences.

Analysis of the epigenetics of meiotic silencing and its role in germ cell loss Jeffrey M Cloutier University College London and National Institute for Medical Research PhD Supervisor: James MA Turner A thesis submitted for the degree of Doctor of Philosophy University College London 2016. 2 Declaration I, Jeffrey M Cloutier, confirm that the work presented in this thesis is my own. Where.

This thesis explores Doris Lessing’s writing of evolution and genetics in her space fiction through two contexts: first, through a historical global crisis for capitalism in the 1970s following a temporary breakdown of post-war Euro-US financial hegemony; and second, through a philosophical shift in scientific discourse from an age of reductionism to an age of complexity or emergence.

Declaration I hereby declare that the thesis is my original work. The work and data presented in the thesis were performed independently. X-ray crystallography, NMR titration experiments, NMR structure determination, and.

This thesis contributes to our understanding of CRC epigenetics through the identification of consistently hypermethylated regions and suggests a mechanism by which hypermethylation occurs in a subset of CIMP-High tumours. Loci identified in this study can accurately discriminate CRC from non-cancerous tissue and could be developed into a.

Since the discovery of cell-free fetal DNA in the circulation of pregnant women fetal-specific DNA biomarkers for non-invasive prenatal diagnosis of fetal aneuploidy have been sought. A model system assessing the DNA methylation of placental DNA and adult peripheral leukocyte DNA has been developed previously to represent fetal and maternal plasma DNA.

This PhD thesis aimed to identify the genetic and epigenetic factors in alcohol and tobacco misuse in adolescence. The impact of life stress and circadian system on reward sensitivity and substance use was investigated in over 2000 adolescents from the IMAGEN Study. In the first study, both negative life events and ventral striatal activations.

This thesis takes inspiration from the elds of genetics and epigenetics, and builds a com-putational model which captures the bene cial properties of epigenetics in silico. This com-putational model is referred to as the arti cial epigenetic network. The arti cial epigenetic.

Ruoji Zhou PhD Thesis Defense Seminar, Genetics and Epigenetics Program. MD Anderson UTHealth Graduate School of BIomedical Sciences PhD Thesis Defense Seminar.

Visvanathan et al. (2019) Genes 10, 141. Amini et al. (2019) J. Cell. Physiol., in press. (Bermejo et al. (2019) Epigenomics 11, 81. Bure et al. (2018) Genes Chrom.

Dr Borko Amulic BSc, PhD, (Lecturer in Immunology), We want to understand how neutrophils are regulated at the molecular level and to use these insights to interrogate their function in immunity and inflammation. We also aim to develop therapies targeting neutrophils in malaria, a devastating disease that affects millions of people in developing countries.

The goal of the Molecular Cell Biology and Oncology (MCBO) PhD program is to offer flexible and diverse training opportunities in biochemistry, molecular cell biology, and oncology, including aspects of anticancer-immunity. The program equips PhD students with the skills to pursue a scientific career in basic and applied biomedical sciences.